Position specification
Doctoral Researcher Position: Plasma Proteomic Biomarkers for Early Cancer Detection
Four-year doctoral researcher position hosted by a small computational diagnostics company developing a plasma proteomic platform for early-stage cancer detection. The position is jointly supervised with a European academic partner that will award the doctoral degree.
Project scope. The successful candidate will contribute to the development of a clinically deployable biomarker pipeline based on plasma LC-MS proteomics. Work spans the full pipeline: sample handling protocols, data acquisition and processing, statistical biomarker discovery, machine learning for predictive classifier development, integration with clinical metadata, and validation against independent cohorts. The candidate will be expected to contribute to platform engineering decisions — assay parameters, processing infrastructure, classifier architecture — rather than working only at the statistical end of the pipeline.
Required qualifications. MSc in bioinformatics, computational biology, molecular biology, biomedical sciences, data science, or a closely related field. Awarded or expected by start date. Candidates already holding a PhD are not eligible.
Eligibility. Standard EU doctoral mobility rules apply: the candidate must not have resided or carried out their main activity in the host country for more than 12 months in the 36 months immediately before recruitment. Working language: English.
Required skills. Programming proficiency in Python and/or R. Solid grounding in applied statistics. Hands-on experience with at least one of: mass-spectrometry proteomics, machine learning, multi-omics data integration, clinical data analysis. Demonstrated ability to deliver an end-to-end research project (defended thesis, conference contribution, or equivalent).
Organisation context
The host is a small (under ten people), well-funded biotech currently scaling its technical platform following a recent funding round. The team is in build mode: the immediate priority is delivering a robust, clinically deployable pipeline that meets the technical specifications the company has committed to.
Operating values. The team operates with a strong delivery orientation. Successful contributors are technically deep, ship code that runs in production, and engage substantively with the methodological choices that determine platform performance. The company values verifiable technical capability — peer-reviewed publications, released code, reproducible benchmarks — over potential or aspiration.
What success looks like. Successful hires bring substantive technical depth that is verifiable from their record (publications, shipped artefacts, presented work), have demonstrated end-to-end delivery on comparable problems, and operate well in a small team where every hire is expected to take meaningful ownership of a piece of the platform.
Per-candidate component scores
| Component | P(X=1) |
|---|---|
| Education | 0.99 |
| Eligibility | 0.95 |
| Technical skills | 0.95 |
| Domain | 0.88 |
| Validated output | 0.96 |
| Environmental pedigree | 0.97 |
| Trajectory | 0.72 |
| Cultural alignment | 0.75 |
| Component | P(X=1) |
|---|---|
| Education | 0.99 |
| Eligibility | 0.95 |
| Technical skills | 0.92 |
| Domain | 0.55 |
| Validated output | 0.92 |
| Environmental pedigree | 0.98 |
| Trajectory | 0.78 |
| Cultural alignment | 0.88 |
| Component | P(X=1) |
|---|---|
| Education | 0.99 |
| Eligibility | 0.92 |
| Technical skills | 0.96 |
| Domain | 0.97 |
| Validated output | 0.85 |
| Environmental pedigree | 0.55 |
| Trajectory | 0.92 |
| Cultural alignment | 0.92 |
| Component | P(X=1) |
|---|---|
| Education | 0.99 |
| Eligibility | 0.95 |
| Technical skills | 0.78 |
| Domain | 0.72 |
| Validated output | 0.90 |
| Environmental pedigree | 0.85 |
| Trajectory | 0.82 |
| Cultural alignment | 0.82 |
| Component | P(X=1) |
|---|---|
| Education | 0.93 |
| Eligibility | 0.95 |
| Technical skills | 0.65 |
| Domain | 0.78 |
| Validated output | 0.72 |
| Environmental pedigree | 0.80 |
| Trajectory | 0.88 |
| Cultural alignment | 0.65 |